Secretion of the orgC gene product by Salmonella enterica serovar Typhimurium.
نویسندگان
چکیده
HilA activates the transcription of genes on Salmonella pathogenicity island 1 (SPI1), which encodes a type III secretion system (TTSS). Previous studies showed that transposon insertions in orgC, a gene located on SPI1, increase hilA expression. We characterize the orgC gene product and show that it is secreted via the SPI1 TTSS. We propose a model whereby OrgC functions as a secreted repressor of the SPI1 virulence genes.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 71 11 شماره
صفحات -
تاریخ انتشار 2003